2015-03-31 · Systemic lupus erythematosus (SLE) is a complex, autoimmune disorder that can have debilitating effects on various organs, including the kidneys. Here, Mohan and Putterman discuss the genetic

Studies have demonstrated considerable variability in systemic lupus erythematosus (SLE) incidence and prevalence estimates. Lack of reliable

Previous studies show that SLE is characterized by autoimmune, inflammatory processes, and tissue destruction. Some seriously-ill patients could develop Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. Symptoms of these diseases can affect many different body systems, including joints, skin, kidneys, blood cells, heart, and lungs. 2021-02-08 · There are several kinds of lupus.

Objective: To study SLE risk, manifestations and severity in relation to urban versus rural residence. PubMed PMID: 27730061; PubMed Central PMCID: PMC5038126. 12: Drehmer MN, Andrade D, Pereira IA, Marrero AR, Muniz YC, de Souza IR, Löfgren SE. Estrogen receptor alpha gene (ESR1) polymorphism can contribute to clinical findings in systemic lupus erythematosus patients. Lupus. 2016 Sep 27.

Daratumumab, a human monoclonal antibody that targets CD38, depletes plasma cells and is approved for the treatment of multiple myeloma. Long-lived plasma cells are implicated in the pathogenesis of systemic lupus erythematosus because they secrete autoantibodies, but they are unresponsive to standa …

Cutaneous lupus erythematosus is classified into acute, subacute, chronic and intermittent lupus erythematosus [ 11, 12 ]. In 2004, the European Society of Cutaneous Lupus Erythematosus was founded to achieve a general consensus on evidence-based clinical standards for disease assessment [ 13 ].

Neonatal lupus erythematosus is an uncommon maternal auto-antibody-associated disease characterized by cutaneous, cardiac, hepatic, hematological, neurological, and pulmonary involvement. A retrospective study was performed to review clinical manifestations, investigation results, outcomes of neonatal lupus erythematosus patients and their mothers at the Department of Pediatrics, Siriraj …

Discoid lupus erythematosus (DLE) is the most common chronic form of cutaneous lupus.It is characterised by persistent scaly, disk-like plaques on the scalp, face, and ears that may cause pigmentary changes, scarring and hair loss.. Lupus erythematosus (LE) is a group of diverse, persistent inflammatory autoimmune diseases and often affects the skin. Lupus, technically known as systemic lupus erythematosus (SLE), is an autoimmune disease in which the body's immune system mistakenly attacks healthy tissue in many parts of the body. Symptoms vary between people and may be mild to severe. Common symptoms include painful and swollen joints, fever, chest pain, hair loss, mouth ulcers, swollen lymph nodes, feeling tired, and a red rash which is 2014-04-09 The heterogeneity of systemic lupus erythematosus (SLE), long recognised by clinicians, is now challenging the entire lupus community, from geneticists to clinical investigators.

Studies of the immunopathogenesis of systemic lupus erythematosus (SLE) have traditionally focused on the mechanisms of generation of the characteristic autoantibodies reactive with nucleic acid-containing intracellular particles and the contribution of autoantibody-autoantigen immune complexes to the inflammation and tissue damage that result in the clinical manifestations of lupus. PubMed PMID: 27014968. 10: Banovic F, Linder KE, Uri M, Rossi MA, Olivry T. Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases). Vet Dermatol.
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The pharmacological management of systemic lupus erythematosus (SLE) is challenging owing to its unpredictable clinical course, the variable organ system involvement and the lack of clear understanding of disease pathogenesis. The widely used corticosteroids and immunosuppressive drugs, which can control disease activity, have serious, potentially Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) … PubMed PMID: 27014968. 10: Banovic F, Linder KE, Uri M, Rossi MA, Olivry T. Clinical and microscopic features of generalized discoid lupus erythematosus in dogs (10 cases).

Few HRQOL studies in SLE patients have focused on African Americans despite an increased disease burden compared with Caucasians. OBJECTIVE: Systemic lupus erythematosus (SLE) is a chronic, relapsing-remitting autoimmune disorder that involves multiple organ systems including the central nervous system. Among the items included in the nomenclature for neuropsychiatric SLE, mood disorders have been identified. Introduction: Systemic lupus erythematosus (SLE) is a relapsing and remitting multiorgan disease associated with significant morbidity and mortality.
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Neonatal lupus erythematosus is an uncommon maternal auto-antibody-associated disease characterized by cutaneous, cardiac, hepatic, hematological, neurological, and pulmonary involvement. A retrospective study was performed to review clinical manifestations, investigation results, outcomes of neonatal lupus erythematosus patients and their mothers at the Department of Pediatrics, Siriraj …

In 2004, the European Society of Cutaneous Lupus Erythematosus was founded to achieve a general consensus on evidence-based clinical standards for disease assessment [ 13 ]. The SLICC criteria introduced an essentially complete list of these manifestations, which, with chronic cutaneous LE, included hypertrophic (verrucous) lupus, lupus panniculitis (lupus profundus), mucosal lupus, lupus erythematosus tumidus, chilblains lupus and discoid lupus/lichen planus overlap, in addition to localized or generalized classic discoid rash . Henegar CE, Eudy AM, Kharat V, et al. Progressive multifocal leukoencephalopathy in patients with systemic lupus erythematosus: a systematic literature review.